Desde hace tiempo se conocen los excelentes resultados de la acupuntura y electroacupuntura en el tratamiento de la xerostomía (boca seca). Siendo ésta una complicación frecuente en pacientes afectos de cáncer de cabeza y/o cuello que han sido irradiados y sometidos a quimioterapia.
La xerostomía se agrava en aquellos pacientes que han perdido las piezas dentarias a consecuencia del debilitamiento del tejido óseo y dentario, para los que supone un verdadero calvario utilizar prótesis removibles.
En la revista Cáncer, Wong, James y colaboradores publicaron un estudio realizado en Canadá, en el que se obtuvo una mejoría significativa en el 86% de los casos.
A continuación el abstract.
Cancer. 2012 Jan 17. doi: 10.1002/cncr.27382. [Epub ahead of print]
Phase 2 results from Radiation Therapy Oncology Group Study 0537: A phase 2/3 study comparing acupuncture-like transcutaneous electrical nerve stimulation versus pilocarpine in treating early radiation-induced xerostomia.
McMasterUniversity, Department of Oncology,JuravinskiCancerCenter,Hamilton,Ontario,Canada. email@example.com.
In this phase 2 component of a multi-institutional, phase 2/3, randomized trial, the authors assessed the feasibility and preliminary efficacy of acupuncture-like transcutaneous electrical nerve stimulation (ALTENS) in reducing radiation-induced xerostomia.
Patients with cancer of the head and neck who were 3 to 24 months from completing radiotherapy with or without chemotherapy (RT ± C) and who were experiencing xerostomia symptoms with basal whole saliva production ≥0.1 mL per minute and were without recurrence were eligible. Patients received twice weekly ALTENS sessions (24 sessions over 12 weeks) using a proprietary electrical stimulation unit. The primary study objective was to assess the feasibility of ALTENS treatment. Patients were considered compliant if 19 of 24 ALTENS sessions were delivered, and the targeted compliance rate was 85%. Secondary objectives measured treatment-related toxicities and the effect of ALTENS on overall radiation-induced xerostomia burden using theUniversityofMichigan Xerostomia-Related Quality of Life Scale(XeQOLS).
Of 48 accrued patients, 47 were evaluable. The median age was 60 years, 84% of patients were men, 70% completed RT ± C for >12 months, and 21% had previously received pilocarpine. Thirty-four patients completed all 24 ALTENS sessions, 9 patients completed 20 to 23 sessions, and 1 patient completed 19 sessions, representing a 94% total compliance rate. Six-month XeQOLS scores were available for 35 patients and indicated that 30 patients (86%) achieved a positive treatment response with a mean ± standard deviation reduction of 35.9% ± 36.1%. Five patients developed grade 1 or 2 gastrointestinal toxicity, and 1 had a grade 1 pain event.
The current results indicated that ALTENS treatment for radiation-induced xerostomia can be delivered uniformly in a cooperative, multicenter setting and produces possible beneficial treatment response. Given these results, the phase 3 component of this study was initiated. Cancer 2011. © 2011 American Cancer Society.
Copyright © 2011 American Cancer Society.