Dolor en el cáncer. Tratamiento mediante electroacupuntura.II

La experiencia clínica en el tratamiento del dolor en el cáncer mediante electroacupuntura es positiva. Especialmente en los tumores óseos primitivos y en las metástasis óseas. Recuerdo especialmente dos casos, con metástasis en costillas y en columna lumbar con un sustancial alivio del dolor. En estos casos, en los que el paciente se encuentra en terapia antitumoral, polimedicado, es muy importante evitar la sobre medicación, especialmente de los opioides exógenos. La mejoría del dolor aumenta la calidad de vida del paciente, lo cual es mucho.

Se conoce perfectamente el mecanismo de la analgesia de la electroacupuntura a nivel metamérico (asta posterior de la médula) y suprasegmentario. Para que se produzcan ambos efectos se deben elegir puntos ubicados en la metámera afectada por el dolor y puntos generales de acupuntura en distintos segmentos del cuerpo. En Korea del Sur han hecho un estudio punturando sólo Suzanli (36E) en ratas con dolor neuropático. A continuación el abstract del trabajo.

Acupunct Electrother Res. 2009;34(1-2):27-40.

Substance P and beta endorphin mediate electroacupuncture induced analgesic activity in mouse cancer pain model.

Lee HJLee JHLee EOLee HJKim KHLee KSLee CHNam DWKim SHLee HJAhn KS.

Source

Cancer Preventive Material Development Research Center and Institute, College of Oriental Medicine, Kyung-Hee University, Seoul 130-701, South Korea.

Abstract

Cancer pain impairs the quality of life of cancer patients, but opioid analgesics can not only cause inhibition of respiratory function, and constipation, but also other significant side effects such as addiction and tolerance that further decrease quality of life. Thus, in the present study, the effects of electro-acupuncture treatment (EA) on mechanical allodynia were examined in cancer pain mouse model. In order to induce neuropathic cancer pain model, S-180 sarcoma cells were inoculated around the sciatic nerve of left legs of Balb/c mice. The mass of S-180 cancer cells embedded around sciatic nerve in a time course was confirmed by Magnetic Resonance Imaging (MRI) scanning. Mechanical allodynia was most consistently induced in mouse sarcoma cell line S-180 (2 x 10(6) sarcoma cells) treated group among all groups. EA stimulation (2Hz) was daily given to ST36 (Zusanli) of S-180 bearing mice for 30 min for 9 days after S-180 inoculation. EA treatment significantly prolonged paw withdrawal latency from 5 days after inoculation as well as shortened cumulative lifting duration from 7 days after inoculation compared with tumor control. In addition, the overexpressions of pain peptide substance P in dorsal horn of spinal cord were significantly decreased in EA treated group compared with tumor control on Day 9 after inoculation. Furthermore, EA treatment effectively increased the concentration of beta endorphin in blood and brain of mice more than tumor control as well as normal group. The concentration of beta-endorphin for EA treatment group increased by 51.457% in blood 12.6% in brain respectively, compared with tumor control group. These findings suggest that S-180 cancer pain model can be a consistent and short time animal model and also EA treatment can be an alternative therapeutic method for cancer pain via decreased substance P and increased beta endorphin.

 

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